CK-MB

462

Enzymes

Creatine kinase MB isoenzyme (CK-MB)

Serum or plasma containing heparin

R1: 2 x 41.5 mL;
R2: 2 x 10.5 mL,
Ready to use

Instructions for Use  |  Safety Data Sheet

For professional use only.

Creatine kinase exists in 3 cytoplasmic forms: CK-MB (in cardiac muscle only), CK-MM (in striated and cardiac muscle) and CK BB (especially in brain). Determination of CK in serum is used for the diagnosis and the follow-up of cardiac muscle damages. In myocardial infarction, the rates of total CK and CK-MB increase quickly until reaching a peak 10-24h after the onset of the infarction. The levels return to normal within 3 to 4 days. CK-MB levels higher than normal can also be observed after muscle damages.

The CKMB SL reagent contains an antibody that specifically inhibits the CK-M subunits (i.e. 100% of the CK-MM isoenzymes and 50% of the CK-MB isoenzymes). The remaining activity, corresponding to the activity of the CK-B fraction, is measured according to the IFCC reference method for measuring CK activity. The CK-MB task is then obtained by multiplying the remaining activity by 2.

Store at 2 - 8°C and protect from direct light. When correctly stored, the reagents are stable up to the expiry date reported on the label. A slight variation in the composition of the reagents may occur between batches, but this has no effect on the test results. The reagents are liquid, ready to use. The solutions must be limpid with no evident precipitate. Pay attention to avoid bacterial contamination during use. The stability of the reagents are 30 days if closed, stored at 2 - 8°C and protect from direct light. Preparation: mix 4 volumes of Reagent R1 with 1 volume of Reagent R2. The working reagent is stable 7 days if stored refrigerated. Do not use the product if there is physical evidence of deterioration (ex. particle matter)

CK-MB Calibrator (R0300000100)
CK-MB Control (R0400000400)