C1 Esterase Inhibitor

192

Specific Proteins

C1 Esterase Inhibitor (C1-INH)

Fresh serum

R1 (Buffer): 1 x 50.0 mL;
R2 (Antiserum): 1 x 5.0 mL,
Ready to use

Instructions for Use  |  Safety Data Sheet

For professional in vitro diagnostic use only.

C1INH is an α2-globulin that controls the first stage of the classical complement pathway and also inhibits plasmin, thrombin and kallikrein. C1INH is very important in the diagnosis of hereditary angioneurotic oedema; a disease characterised by subcutaneous, bronchial and gastrointestinal oedema. Laboratory findings include low levels of C4 and C1INH, but normal levels of C3. In about 15% of the cases, levels of C1 esterase inhibitor are normal, but the protein is non-functional. In such cases, a functional assay for the inhibitor is essential to diagnosis.

Measurement of antigen-antibody reaction by the end-point method.

The reagents are stable until expiry date when kept at 2-8°C. Stability in the instrument is at least 4 weeks if contamination is avoided. Do not freeze.

Saline (9 g/L NaCl)
Protein Calibrator High, 1 mL (R1300002501)
Immunology Control Low (R1400000901)
Immunology Control High (R1400001001)